HORMONAL-REGULATION OF SIALIC ACID-BINDING (SAS) PROTEIN-SYNTHESIS OFRAT UTERUS

Sialic acid binding proteins (SAS) of rat uteri have been found in all three stages of the estrous cycle. To study the control of synthesis of these proteins two different animal models were used I-immature fem ale rats (25 d) where the hormones estradiol (E2) and progesterone (P4 ) were given separately and together, and II-adult female rats where h ormone treatment commenced 14 days after ovariectomy. The data indicat ed that E2 initiated the synthesis of SAS proteins in the immature ani mals, while P4 could inhibit SAS synthesis, either given alone or toge ther with E2. However, prior priming of the rat with E2 and subsequent administration of P4 stimulated SAS protein synthesis.