ANTIOXIDATIVE STATE OF THE MYOCARDIUM AND KIDNEYS IN ACUTE DIABETIC RATS

The influence of acute diabetes (8 days), induced by streptozotocin (4 5 mg.kg-1 body weight) on myocardial and renal antioxidative condition s was investigated. The animals were given subtherapeutical doses of i nsulin (Interdep 6 U. kg-1 body weight, s.c.). Considerably increased levels of malondialdehyde (MDA), as well as of superoxide dismutase (S OD) and catalase (CAT) activity were found in the myocardium of diabet ic animals.The oxidized glutathione (GSSG) level and glutathione perox idase (GSH-PX) activity remained unchanged. The reduced glutathione (G SH) level as well as the activity of glutathione S-transferase (GST) w ere significantly lower. The activity of GSH-PX in the kidneys of diab etic rats increased by 60% and that of GST by 105%, respectively. CAT and SOD activity values were unchanged.