HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC METHOD FOR THE MONITORING OF THE SYNTHESIS OF THE PRECURSOR FOR TETRAMISOLE

The synthesis of the monochloro precursor C6H2CH2(OH)CH2NHCH2CH2Cl is the crucial step in the synthesis of the important anthelmintic drug t etramisole. HPLC methods using mobile phases consisting of methanol, w ater and acetonitrile in various combinations together with ammonium c hloride as an inorganic modifier and Nova-Pak C18 and muPorasil column s were developed for the monitoring and quantification of each step of the synthesis of the precursor. The methods provide important clues f or increasing the yield of the product.