MICROIONTOPHORESIS OF BACLOFEN ON MEMBRANE-POTENTIAL AND INPUT RESISTANCE IN BULBAR RESPIRATORY NEURONS IN THE CAT

Authors
HAJI A TAKEDA R
Citation
A. Haji et R. Takeda, MICROIONTOPHORESIS OF BACLOFEN ON MEMBRANE-POTENTIAL AND INPUT RESISTANCE IN BULBAR RESPIRATORY NEURONS IN THE CAT, Brain research, 622(1-2), 1993, pp. 294-298
Citations number
17
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
622
Issue
1-2
Year of publication
1993
Pages
294 - 298
Database
ISI
SICI code
0006-8993(1993)622:1-2<294:MOBOMA>2.0.ZU;2-N
Abstract
Iontophoresis of baclofen produced hyperpolarization-and a decrease in input resistance in 32 neurons and no effect in 24 neurons of the ven tral respiratory group in cats. Iontophoresed phaclofen antagonized th e effect of baclofen, but had negligible effects on periodic fluctuati ons in membrane potential and spike activity in these neurons. The hyp erpolarizing effect of baclofen persisted after iontophoresis of tetro dotoxin, suggesting that baclofen acted directly at the postsynaptic g amma-aminobutyric acid (GABA)B receptors.