NEURONAL INJURY IN EXPERIMENTAL STATUS EPILEPTICUS IN THE RAT - ROLE OF ACIDOSIS

Systemic and cerebral acidosis accompanies generalized tonic-clonic se izures and status epilepticus. Acidosis during status may be modified by neuromuscular paralysis, intubation and ventilation, or administrat ion of a base, but the effect of acidosis on neuronal injury from stat us is uncertain. We studied the effect of acidosis, induced by hyperca rbic ventilation, on heat-shock protein (HSP72) induction in rat brain as a measure of neuronal injury in experimental status epilepticus. A cidosis was found to attenuate neuronal injury, independent of its ant iconvulsant effect. (C) 1997 Elsevier Science Ireland Ltd.