RENIN-ALDOSTERONE RESPONSE TO DEXAMETHASONE IN GLUCOCORTICOID-SUPPRESSIBLE HYPERALDOSTERONISM IS ALTERED BY COEXISTENT RENAL-ARTERY STENOSIS

The responses of renin, aldosterone, and blood pressure to ACTH suppre ssion with dexamethasone in a 61-yr-old man with glucocorticoid-suppre ssible hyperaldosteronism were modified by coexistent atheromatous ren al artery stenosis (RAS). The apparent responsiveness of aldosterone t o angiotensin-II resulting from RAS has implications for the regulatio n of steroidogenesis in this condition. After successful surgical corr ection of the RAS, the response changed and resembled that seen in two younger males (one his son) with uncomplicated glucocorticoid-suppres sible hyperaldosteronism.