SWEETS-SYNDROME ASSOCIATED WITH G-CSF

Sweet's syndrome (SS) developed in two patients with acute myeloid leu kaemia (AML) treated with granulocyte colony stimulating factor (G-CSF ) for febrile neutropenia due to AML chemotherapy. Fever, painful skin and conjunctival lesions developed and neutrophilic infiltration was detected at biopsy specimens. Neutrophilia was not detected. Skin lesi ons regressed within 1-2 weeks and conjunctival lesions within 4 weeks following the cessation of G-CSF. We conclude that SS may be a compli cation of G-CSF therapy and tender skin and/or conjunctival lesions de veloping during G-CSF therapy should suggest the possibility of SS.