PHAGE DISPLAY OF PEPTIDES AND PROTEIN DOMAINS

Phage display of peptides and proteins is a versatile and promising to ol for protein engineering and drug discovery programs because of the vast libraries of sequences that can be rapidly screened for biologica l function. Over the past year, reports have appeared in which these l ibraries have been used to investigate the binding properties of a var iety of receptors. Several functional protein domains have also been d isplayed. A novel selection scheme using both protein and peptide disp lay has been devised for determining protease cleavage specificity.