Sk. Sharma et Mw. Davies, PATIENT-CONTROLLED ANALGESIA WITH A MIXTURE OF MORPHINE AND DROPERIDOL, British Journal of Anaesthesia, 71(3), 1993, pp. 435-436
In a prospective study, 50 women who had undergone uncomplicated abdom
inal hysterectomy under general anaesthesia were allocated randomly to
receive patient-controlled analgesia with either morphine alone or a
mixture of morphine and droperidol. Bolus doses of morphine 1 mg and d
roperidol 0.05 mg were used with a lockout time of 5 min. During the f
irst 24 h after surgery the mean (range) dose of droperidol in the dro
peridol group was 3.2 (1.9-6.0) mg. Significantly fewer patients in th
e droperidol group felt nauseated (P < 0.01) and significantly fewer v
omited (P < 0.001). In the morphine alone group, 19 patients required
additional antiemetic therapy, whereas in the droperidol group only on
e patient found this necessary (P < 0.001). Extrapyramidal side effect
s were not observed in any patient. Significantly more patients were o
f the opinion that PCA had provided excellent analgesia when droperido
l had been used (P < 0.01).