RESISTANCE OF PLASMODIUM-FALCIPARUM TO AMODIAQUINE IN PAPUA-NEW-GUINEA

Authors
TRENHOLME KR KUM DE RAIKO AK GIBSON N NARARA A ALPERS MP
Citation
Kr. Trenholme et al., RESISTANCE OF PLASMODIUM-FALCIPARUM TO AMODIAQUINE IN PAPUA-NEW-GUINEA, Transactions of the Royal Society of Tropical Medicine and Hygiene, 87(4), 1993, pp. 464-466
Citations number
21
Categorie Soggetti
Public, Environmental & Occupation Heath","Tropical Medicine
Journal title
Transactions of the Royal Society of Tropical Medicine and Hygiene → ACNP
ISSN journal
00359203
Volume
87
Issue
4
Year of publication
1993
Pages
464 - 466
Database
ISI
SICI code
0035-9203(1993)87:4<464:ROPTAI>2.0.ZU;2-3
Abstract
The sensitivity of Plasmodium falciparum to amodiaquine was assessed i n children in the Madang region of Papua New Guinea. Fifty-four tests in vivo were carried out and 19 (35%) of these showed resistance at th e RII or RIII level. Twenty-two of the 43 isolates tested showed some degree of resistance to amodiaquine in vitro. A negative correlation b etween the age of the patient and apparent resistance of the parasite in vivo was observed. There was no correlation between resistance in v ivo and in vitro.