ON THE PLANNING OF SAMPLES FOR LINKAGE AN ALYSIS INFORMATIVITY OF PEDIGREES

Comparison of Kullback's information on nuclear pedigrees with differe nt numbers of offsprings was performed in a case when a marker gene wa s codominant and the recessive or dominant control with complete penet rance was supposed for the localized gene. This comparison resulted in some conclusions about optimization of the sample collection. These c onclusions are found to be invariant with respect to the recombination fraction value determined by the simple alternative hypothesis, to th e population frequencies of the genes considered and, within certain l imits, to the disequilibrium parameter values.