Degeneration of the central white matter is described in old dogs. The
presence of ubiquitin-immunoreactive free granules and intracytoplasm
ic globules in glial cells and macrophages, together with galactocereb
roside-immunoreactive precipitates and lipofuscin storage, point to th
e likelihood of a primary myelin degeneration with deposits of non-deg
raded ubiquitin-protein conjugates and complex galactolipids.