THE EFFECT OF DIFFERENT PROSTAGLANDINS ON GASTRIC-MUCOSAL INTRACELLULAR 2ND MESSENGER SYSTEM IN THE RAT

After an oral administration of 100 mug/kg dose, the investigated pros taglandins: - PGF2alpha, PGE2 and a synthetic PGE2 derivative: FCE-207 00, - exerted a significant effect on cAMP and cGMP content of both pa rts (antral and fundic) of gastric mucosa, resulting in an elevated cA MP/cGMP ratio, while 6-keto-PGF1alpha, the stable break-down product o f prostacyclin, was inactive. Since the above-mentioned phenomenon see ms to be proportionate to the cytoprotective (anti-ulcerogenic) proper ty of the investigated prostaglandins, this cAMP/cGMP ratio ''shift'' is interpreted as a probable (molecular) sign of the reparative, (anti -ulcerogenic) processes.