CHROMOSOMAL DISTRIBUTION OF 320 GENES FROM A BRAIN CDNA LIBRARY

We have determined the chromosomal assignment of 320 brain expressed g enes by studying the segregation of polymerase chain reaction (PCR) pr oducts in human rodent somatic cell hybrids and by genetically mapping polymorphic cDNAs using the CEPH (Centre d'Etude du Polymophisme Huma ine) reference pedigrees and database. These mapped genes can function as markers on the physical map of the human genome, as well as serve as candidate disease gene loci. Distribution of these genes to the hum an chromosomes correlates well with the GC content of the chromosomes. However, the distribution of these genes does not correlate well with the cytogenetic length of each chromosome.