FLUORINATION OF FORSKOLIN AND 1,9-DIDEOXYFORSKOLIN

Authors
LAL B JOTWANI BR GIDWANI RM
Citation
B. Lal et al., FLUORINATION OF FORSKOLIN AND 1,9-DIDEOXYFORSKOLIN, Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry, 36(1), 1997, pp. 1-4
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry → ACNP
ISSN journal
03764699
Volume
36
Issue
1
Year of publication
1997
Pages
1 - 4
Database
ISI
SICI code
0376-4699(1997)36:1<1:FOFA1>2.0.ZU;2-W
Abstract
13-Formyl-1,9-protected-forskolin 3 is reacted with bromodifluorotriph enylyhosphonium bromide 4 to give 15,15-difluoro-1,9-protected-forskol in 5 which on deprotection affords the 15,15-difluoroforskolin 7. Iodo fluorination at 14,15-double bond of 1,9-dideoxyforskolin 8 followed b y base promoted dehydroiodination gives the required 14-fluorodideoxyf orskolin 10 and the corresponding 7-acetyl migrated product 11.