PHARMACODYNAMIC INTERACTION OF CLONIDINE AND MUSCIMOL IN HYPERTENSION

Authors
JASTRZEBSKI Z GOZLINSKA B CZYZEWSKASZAFRAN H
Citation
Z. Jastrzebski et al., PHARMACODYNAMIC INTERACTION OF CLONIDINE AND MUSCIMOL IN HYPERTENSION, Research communications in chemical pathology and pharmacology, 81(1), 1993, pp. 113-116
Citations number
12
Categorie Soggetti
Pharmacology & Pharmacy",Pathology
Journal title
Research communications in chemical pathology and pharmacology → ACNP
ISSN journal
00345164
Volume
81
Issue
1
Year of publication
1993
Pages
113 - 116
Database
ISI
SICI code
0034-5164(1993)81:1<113:PIOCAM>2.0.ZU;2-E
Abstract
The effect of the GABA agonist muscimol on the hypotensive action of c lonidine in SHR was investigated. Muscimol administered before clonidi ne significantly (p < 0.01) intensified clonidine-induced reduction of blood pressure. This effect was achieved at muscimol doses which them selves had no influence on blood pressure. Muscimol injected after clo nidine was ineffective. Our data suggest that the muscimol-clonidine i nteraction occurs at the level of GABAergic neurotransmission since bo th agents have been proved to activate the function of GABAergic neuro ns.