M. Murugesan et K. Kaniappan, INDOLIZATION OF 4-PIPERIDONES - SYNTHESIS OF 1,3-DIPHENYL-1,2,3,4-TETRAHYDRO-GAMMA-CARBOLINES, Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry, 36(1), 1997, pp. 83-85
Several 1,3-diphenyl-1,2,3,4-tetrahydro-gamma-carbolines (2) have been
synthesized from the corresponding 2,6-diphenylpiperidin-4-ones by us
ing formic acid as a solvent as well as cyclizing agent. A one-step sy
nthesis of gamma-carboline from 2,6-diphenylpiperidin-4-ones using for
mic acid and glacial acetic acid respectively is also reported.