Neovascular glaucoma has been reported in the setting of carotid occlu
sive disease. Its pathophysiology after carotid endarterectomy in this
setting is unclear, and it may represent a unique entity. A patient w
ho developed neovascular glaucoma shortly after ipsilateral carotid en
darterectomy was examined and her clinical course. A 72-year-old women
presented with visual loss in the left eye of 1 week's duration. A di
agnosis of recanalized central retinal artery occlusion of the left ey
e was made based on clinical examination and fluorescein angiogram. Af
ter a medical evaluation revealed carotid occlusive disease, the patie
nt underwent ipsilateral carotid endarterectomy. On follow up, she had
an intraocular pressure of 38 mm Hg OS with diffuse rubeosis on gonio
scopy. The patient underwent pan-retinal photocoagulation with complet
e regression of rubeosis. We speculate that the sudden reperfusion aft
er endarterectomy, which occurs in patients with combined central reti
nal artery occlusion and carotid occlusive disease, may enhance the ci
rculation of preformed angiogenesis factors, leading to the developmen
t of neovascularization. Frequent and careful surveillance of patients
with central retinal artery occlusion that is associated with carotid
occlusive disease if an ipsilateral carotid endarterectomy is recomme
nded.