MULTIPLE PRIMARY GYNECOLOGIC NEOPLASMS IN A YOUNG HIV-POSITIVE PATIENT

Immune suppression from human immunodeficiency virus (HIV) infection i s frequently associated with the development of certain neoplasms, inc luding Kaposi's sarcoma and non-Hodgkin's lymphoma. A young patient wi th a 5-year history of HIV infection was found simultaneously to have invasive carcinoma of the breast, microinvasive carcinoma of the cervi x, and intraepithelial neoplasia of the vulva. In view of the early na ture of these neoplasms, conservative therapy was utilized; lumpectomy and adjuvant radiation therapy, conservative hysterectomy, and local therapy for the breast carcinoma, cervical carcinoma and vulvar intrae pithelial neoplasia, respectively. Epithelial malignancies appear to b e more common in the HIV-positive population than previously appreciat ed. To our knowledge this is the first report of multiple primary gyne cologic neoplasms in association with HIV infection. (C) 1993 Wiley-Li ss, Inc.