PREPARATION OF AMINATED TAXOL SIDE-CHAIN PRECURSORS - A SIMPLE APPROACH TO 2,3-DIAMINO ACIDS USING THE BETA-LACTAM SYNTHON METHOD

Authors
MOYNA G WILLIAMS HJ SCOTT AI
Citation
G. Moyna et al., PREPARATION OF AMINATED TAXOL SIDE-CHAIN PRECURSORS - A SIMPLE APPROACH TO 2,3-DIAMINO ACIDS USING THE BETA-LACTAM SYNTHON METHOD, Synthetic communications, 27(9), 1997, pp. 1561-1567
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthetic communications → ACNP
ISSN journal
00397911
Volume
27
Issue
9
Year of publication
1997
Pages
1561 - 1567
Database
ISI
SICI code
0039-7911(1997)27:9<1561:POATSP>2.0.ZU;2-V
Abstract
Coupling-ready aminated side chain analog precursors of the anticancer drug taxol were prepared through the beta-lactam synthon method. The procedure described represents an easy connection between beta-lactams and 2,3-diamino acids, is highly stereospecific, and causes no racemi zation due to vicinal group participation.