A SHORT AND VERSATILE SYNTHESIS OF 3-SUBSTITUTED 2-AMINOQUINOLINES

Authors
COMPAGNONE RS SUAREZ AI ZAMBRANO JL PINA IC DOMINGUEZ JN
Citation
Rs. Compagnone et al., A SHORT AND VERSATILE SYNTHESIS OF 3-SUBSTITUTED 2-AMINOQUINOLINES, Synthetic communications, 27(9), 1997, pp. 1631-1641
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthetic communications → ACNP
ISSN journal
00397911
Volume
27
Issue
9
Year of publication
1997
Pages
1631 - 1641
Database
ISI
SICI code
0039-7911(1997)27:9<1631:ASAVSO>2.0.ZU;2-2
Abstract
A short and versatile synthesis of a series of 3-substituted -2-aminoq uinolines was accomplished in good yields starting from 2-nitrobenzald ehide. Organic phosphonates were used as key synthetic intermediates a nd in some cases aminoacids as readily available starting materials. T he finals two key steps of the sequence involving a reduction and ring closure that led to the 2-aminoquinoline skeleton were carried out in a ''one pot'' procedure using SnCl2.2H(2)O.