LIQUID-CHROMATOGRAPHIC ANALYSIS OF ANTIBACTERIAL DRUG RESIDUES IN FOOD-PRODUCTS OF ANIMAL ORIGIN

This paper reviews recent developments in the liquid chromatographic ( LC) methods of analysis for the residues of antibiotics (aminoglycosid es, chloramphenicol, sulfonamides, tetracyclines, macrolides, beta-lac tams, etc.) in food products of animal origin. The review also covers clean-up procedures, such as, ultrafiltration, liquid-liquid partition . solid-phase extraction. immunoaffinity, and matrix solid-phase dispe rsion, for use as extraction, deproteination, and concentration steps. The LC methods offer considerable potential for rapid automated analy sis, and some may be used as direct screening for residues in meat and milk.