FUNCTIONAL-ANALYSIS OF THE HUMAN IGF-I GENE PROMOTERS

Authors
STEENBERGH PH JANSEN E VANSCHAIK FMA SUSSENBACH JS
Citation
Ph. Steenbergh et al., FUNCTIONAL-ANALYSIS OF THE HUMAN IGF-I GENE PROMOTERS, Molecular reproduction and development, 35(4), 1993, pp. 365-367
Citations number
4
Categorie Soggetti
Reproductive Biology","Developmental Biology",Biology
Journal title
Molecular reproduction and development → ACNP
ISSN journal
1040452X
Volume
35
Issue
4
Year of publication
1993
Pages
365 - 367
Database
ISI
SICI code
1040-452X(1993)35:4<365:FOTHIG>2.0.ZU;2-E
Abstract
The two putative promoter regions of the human insulin-like growth fac tor-I (IGF-I) gene, located upstream of the two alternatively used lea der exons 1 and 2, were tested for promoter activity in transient tran sfection assays. Both regions were shown to possess promoter activity. The results further indicate cell-type-specific regulation of the act ivities of the two promoters in endogenously IGF-I producing human cel l lines of different origin. (C) 1993 Wiley-Liss, Inc.