METABOLISM OF PHENYLETHANOLAMINES AND 2-OXO-2-PHENYLETHYLAMINES IN THE RAT

Authors
GOODWIN BL RUTHVEN CRJ SANDLER M
Citation
Bl. Goodwin et al., METABOLISM OF PHENYLETHANOLAMINES AND 2-OXO-2-PHENYLETHYLAMINES IN THE RAT, General pharmacology, 28(4), 1997, pp. 535-543
Citations number
43
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
General pharmacology → ACNP
ISSN journal
03063623
Volume
28
Issue
4
Year of publication
1997
Pages
535 - 543
Database
ISI
SICI code
0306-3623(1997)28:4<535:MOPA2I>2.0.ZU;2-A
Abstract
1. The metabolism of a series of phenylethanolamines and 2-oxo-2-pheny lethylamines was examined in vivo in the rat. 2. The urinary excretion of the corresponding mandelic acids was, in general, considerably gre ater for 2-oxo-2 phenylethylamines than for the corresponding phenylet hanolamines. Of the putative metabolites of the former class of compou nds only phenylglyoxals yielded mandelic acids. (C) 1997 Elsevier Scie nce Inc.