A RANDOMIZED DOUBLE-BLIND-STUDY OF FLUOXETINE VERSUS PLACEBO IN THE TREATMENT OF DYSTHYMIA

Objective: The purpose of this study was to assess the efficacy of flu oxetine, a selective serotonergic antidepressant, in the treatment of dysthymia. Method: Thirty-five patients who met criteria for dysthymia , but not major depression, began randomized, double-blind 8-week tria ls of fluoxetine or placebo. Results: Of 32 patients who completed the study, 10 (62.5%) of the 16 patients given fluoxetine and three (18.8 %) of the 16 given placebo responded to treatment. Response was define d as 1) 50% or greater decrease in Hamilton Rating Scale for Depressio n score and 2) a score of 1 or 2 on the Clinical Global Impression (CG I) improvement subscale. Fluoxetine subjects showed significantly grea ter improvement at week 8 than placebo subjects on the Hamilton depres sion and CGI scales, but not on the Hopkins Symptom Checklist (58-item ) or the cornell Dysthymia Rating Scale. Conclusions: When compared to placebo, fluoxetine showed short-term effectiveness in treating dysth ymic symptoms.