MODULATION OF THE ATP INDUCED CA2-30D HEPATOMA-CELLS(!C INCREASE IN AS)

Authors
TORRESMARQUEZ ME MEJIA S MORENOSANCHEZ R
Citation
Me. Torresmarquez et al., MODULATION OF THE ATP INDUCED CA2-30D HEPATOMA-CELLS(!C INCREASE IN AS), International Journal of Biochemistry, 25(8), 1993, pp. 1109-1114
Citations number
27
Categorie Soggetti
Biology
Journal title
International Journal of Biochemistry → ACNP
ISSN journal
0020711X
Volume
25
Issue
8
Year of publication
1993
Pages
1109 - 1114
Database
ISI
SICI code
0020-711X(1993)25:8<1109:MOTAI>2.0.ZU;2-D
Abstract
1. The regulation of the increase in the cytosolic calcium concentrati on (Ca2+!c) induced by extracellular ATP in AS-30D hepatoma cells was studied. 2. Homologous desensitization involving the refilling of int racellular calcium pools and the participation of protein kinase C was found. 3. Isoproterenol, forskolin and dibutyril-cyclic AMP also indu ced an increase in Ca2+!c. 4. Interestingly, synergism was found for isoproterenol or forskolin and ATP. 5. The results suggest that there are two pathways for mobilizing Ca2+!c in AS-30D hepatoma cells; one is activated by ATP receptors and the other by cyclic AMP.