OZONOLYSIS OF 3-AMINO-1-METHYL-5-H-PYRIDO4,3-B!INDOLE (TRP-P-2) - EFFECTS ON THE GENOTOXICITY AND CYTOTOXICITY AND IDENTIFICATION OF THE OZONATION PRODUCTS

Authors
SEGAWA T ISHIGA H UENO H NAKAMURO K SAYATO Y
Citation
T. Segawa et al., OZONOLYSIS OF 3-AMINO-1-METHYL-5-H-PYRIDO4,3-B!INDOLE (TRP-P-2) - EFFECTS ON THE GENOTOXICITY AND CYTOTOXICITY AND IDENTIFICATION OF THE OZONATION PRODUCTS, Chemosphere, 27(4), 1993, pp. 565-576
Citations number
46
Categorie Soggetti
Environmental Sciences
Journal title
Chemosphere → ACNP
ISSN journal
00456535
Volume
27
Issue
4
Year of publication
1993
Pages
565 - 576
Database
ISI
SICI code
0045-6535(1993)27:4<565:OO3(-E>2.0.ZU;2-3
Abstract
Trp-P-2 caused both DNA single-strand breaks and cell injury in rat he patocytes. The ozonation of Trp-P-2 resulted in the suppression of its toxic responses depending on the amount remaining in ozonated solutio n, and the formation of glyoxal, glyoxylic acid, oxalic acid, formalde hyde, formic acid, ammonium ion, nitrite ion and nitrate ion.