ANTIFUNGAL AGENTS .3. NAPHTHYL AND THIENYL DERIVATIVES OF 1H-IMIDAZOL-1-YL-4-PHENYL-1H-PYRROL-3-YLMETHANE

The in vitro antifungal activities of some naphthyl and thienyl deriva tives of 1H-imidazol-1-yl-4-phenyl-1H-pyrrol-3-ylmethane against Candi da albicans and Candida spp are reported. The title derivatives were p repared starting from proper arylstirylketones, which were reacted wit h tosylmethylisocyanide (Tos-MIC) to afford the related 4-phenyl-1H-py rrol-3-yl aryl ketones. Reduction of ketones to the corresponding carb inols followed by treatment of the last compounds with 1,1'-carbonyldi imidazole (CDI) gave the title imidazoles. The related N-methylpyrrole derivatives are also described.