SYNTHESIS, ANTIBACTERIAL AND ANTIFUNGAL ACTIVITY OF METAL (II) COMPLEXES OF 2-ACETYLPYRIDINE THIOSEMICARBAZONES

2-Acetylpyridine-(4-methylthiosemicarbazone), 2-acetylpyridine-(2-meth ylthiosemicarbazone) and their metal (II) complexes have been synthesi zed and characterized by chemical and spectral methods. They were stud ied for their antibacterial, antifungal and amoebicidal activity in vi tro and for their toxicity in vivo. The ligands and their metal (II) c omplexes exibited significant activity against a wide spectrum of micr oorganisms. The metal (II) complexes derived from 2-acetylpyridine-(4- methylthiosemicarbazone) seem to be the most active compounds.