SYNTHESIS OF EPOXYPROPYLOXY CHROMONES AND ALLYL HYDROXY CHROMONES ANDIN-VITRO - IN-VIVO ACTIVITY ON PROTOSCOLECES OF ECHINOCOCCUS-MULTILOCULARIS (CESTODA)

Derivatives with epoxypropyloxy, allyloxy and allyl hydroxy-chromone s tructures were synthesized and tested against protoscoleces of Echinoc occus multilocularis. Compounds IV - IX were tested in vitro and compo und VII proved the most active of them with, at 0.1 mmol. L-1, 98% dea d protoscoleces in open vesicles after 24 hours and 80% in closed vesi cles within 96 hours. Compound VII was tested in vivo on Meriones ungu iculatus infested by Echinococcus multilocularis, but was found to be rather inactive.