DEDIFFERENTIATED CHORDOMA - RESPONSE TO AGGRESSIVE CHEMOTHERAPY IN 2 CASES

Citation
Gf. Fleming et al., DEDIFFERENTIATED CHORDOMA - RESPONSE TO AGGRESSIVE CHEMOTHERAPY IN 2 CASES, Cancer, 72(3), 1993, pp. 714-718
Citations number
21
Categorie Soggetti
Oncology
Journal title
CancerACNP
ISSN journal
0008543X
Volume
72
Issue
3
Year of publication
1993
Pages
714 - 718
Database
ISI
SICI code
0008-543X(1993)72:3<714:DC-RTA>2.0.ZU;2-2
Abstract
Background. Dedifferentiated chordoma is an unusual and aggressive var iant of chordoma which is likely to metastasize. Few reports exist of treatment of these tumors with chemotherapy. Methods. In 1988, two pat ients with dedifferentiated sacral chordomas were seen at the Universi ty of Chicago Hospitals. Both developed metastatic disease less than a year after sacral resection and radiation therapy. These patients' di agnoses, courses, and treatments were reviewed along with the literatu re on chemotherapy in both conventional and dedifferentiated chordomas . Results. Both patients obtained complete remissions, one to a six-dr ug regimen and the other to ifosfamide. Conclusions' A trial of reason ably aggressive chemotherapy is warranted in patients with metastatic dedifferentiated chordoma. The optimum regimen is unclear, but agents active in high-grade sarcomas are logical choices.