MANDIBULOFACIAL DYSOSTOSIS - REPORT ON 2 BRAZILIAN FAMILIES SUGGESTING AUTOSOMAL RECESSIVE INHERITANCE

We report on mandibulofacial dysostosis in 2 brothers born to normal n onconsanguineous parents, and a girl (F = 1/16) born to normal consang uineous parents. Normal clinical, skeletal, audiologic, and cephalomet ric studies in the parents, as well as the absence of limb anomalies i n these children, exclude the autosomal recessive (Nager and Genee-Wid emann) mandibulofacial dysostoses. The data of the present patients as sociated with the few additional reports on mandibulofacial dysostosis recurring in sibs, suggest the possibility of an autosomal recessive Treacher Collins-like mandibulofacial dysostosis. (C) 1993 Wiley-Liss, Inc.