SELECTIVITY IN THE DEHYDRATION OF 15-MEMBERED AZALIDES

Authors
JONES AB ACTON JJ DOSS GA
Citation
Ab. Jones et al., SELECTIVITY IN THE DEHYDRATION OF 15-MEMBERED AZALIDES, Tetrahedron letters, 34(31), 1993, pp. 4913-4916
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
31
Year of publication
1993
Pages
4913 - 4916
Database
ISI
SICI code
0040-4039(1993)34:31<4913:SITDO1>2.0.ZU;2-J
Abstract
Dehydration at the 6-hydroxy group of two isomeric 15-membered azalide s shows opposing regioselectivity. Azithromycin (1)favours the E-DELTA 6,7-isomer while L-701677 (8) generates the DELTA6,18-isomer.