THE SYNTHESIS OF DL-3,3-DIFLUOROGLUTAMIC ACID FROM A 3-OXOPROLINOL DERIVATIVE

Authors
HART BP COWARD JK
Citation
Bp. Hart et Jk. Coward, THE SYNTHESIS OF DL-3,3-DIFLUOROGLUTAMIC ACID FROM A 3-OXOPROLINOL DERIVATIVE, Tetrahedron letters, 34(31), 1993, pp. 4917-4920
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
31
Year of publication
1993
Pages
4917 - 4920
Database
ISI
SICI code
0040-4039(1993)34:31<4917:TSODAF>2.0.ZU;2-Z
Abstract
DL-3,3-Difluoroglutamic acid was synthesized from a masked 3-hydroxypr olinol, 6-hydroxy-l-aza-3-oxabicyclo3.3.0!octan-2-one, in eight steps . The described synthetic route expands the utility of fluoroproline d erivatives as precursors of fluoroglutamic acids.