SYNTHESIS OF ACYCLIC POLYOL DERIVATIVES VIA ENZYME-MEDIATED ALDOL REACTION

Authors
MATSUMOTO K SHIMAGAKI M NAKATA T OISHI T
Citation
K. Matsumoto et al., SYNTHESIS OF ACYCLIC POLYOL DERIVATIVES VIA ENZYME-MEDIATED ALDOL REACTION, Tetrahedron letters, 34(31), 1993, pp. 4935-4938
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
31
Year of publication
1993
Pages
4935 - 4938
Database
ISI
SICI code
0040-4039(1993)34:31<4935:SOAPDV>2.0.ZU;2-8
Abstract
Enzyme-mediated stereoselective aldol reaction between dihydroxyaceton e phosphate (DHAP, 1) and (2R,4R)-6-benzyloxy-2,4-dimethoxyhexanal (8) was catalyzed by rabbit muscle aldolase (RAMA) to generate (3S,4R,5R, 7R)-trihydroxyketone 12, which could be easily transformed to the mask ed polyhydroxylated compound 15 corresponding to the C-9 approximately C-16 segment of pentamycin (6).