Sinus of Valsalva aneurysms are a rare cause of angina or myocardial i
nfarction. We describe a patient with unstable angina and massive unru
ptured aneurysms of both coronary sinuses causing severe distortion of
both coronary ostia, to our knowledge not previously reported. This u
nusual patient underwent aortic valve replacement, ascending aortic re
pair, and coronary artery bypass. At 11-year follow-up, she had develo
ped severe mitral stenosis and prosthetic aortic valve stenosis. Revie
w of the literature reveals 30 reported cases of Sinus of Valsalva ane
urysm complicated by coronary insufficiency or infarction, involving e
ither the left (20 cases) or the right coronary sinus (10 cases). We e
mphasize the poor outcome of these patients, especially if treated con
servatively. (C) 1993 Wiley-Liss, Inc.