RECOVERY OF RESPONSE TO ADRIAMYCIN AND CYCLOPHOSPHAMIDE BY LONIDAMINEIN PREVIOUSLY TREATED METASTATIC BREAST-CANCER PATIENTS

Authors
TOMIROTTI M BERNARDO G EPIFANI C BIASIOLI R FRANCHI R MENSI F CARNAGHI P SCHIEPPATI G SCANNI A
Citation
M. Tomirotti et al., RECOVERY OF RESPONSE TO ADRIAMYCIN AND CYCLOPHOSPHAMIDE BY LONIDAMINEIN PREVIOUSLY TREATED METASTATIC BREAST-CANCER PATIENTS, International journal of oncology, 3(2), 1993, pp. 213-217
Citations number
27
Categorie Soggetti
Oncology
Journal title
International journal of oncology → ACNP
ISSN journal
10196439
Volume
3
Issue
2
Year of publication
1993
Pages
213 - 217
Database
ISI
SICI code
1019-6439(1993)3:2<213:RORTAA>2.0.ZU;2-T
Abstract
Thirty-one patients with metastatic breast cancer not responding or pr ogressing after initial response to adriamycin + cyclophosphamide (AC) treatment entered a phase 11 study with oral lonidamine in associatio n to AC. Objective clinical responses were observed in 10 patients (32 %) and consisted of 1 complete + 9 partial remissions. Disease stabili ty and progression were observed in 8 and 13 cases, respectively. Thes e results were obtained with a marginal toxicity in addition to that a lready reported for AC therapy, the main additional side effect being myalgia, which was easily manageable in most cases.