ASCORBATE-DEPENDENT ELEVATION OF MESSENGER-RNA LEVELS FOR CYTOCHROME-P450S INDUCED BY POLYCHLORINATED-BIPHENYLS

Authors
SUZUKI H TORII Y HITOMI K TSUKAGOSHI N
Citation
H. Suzuki et al., ASCORBATE-DEPENDENT ELEVATION OF MESSENGER-RNA LEVELS FOR CYTOCHROME-P450S INDUCED BY POLYCHLORINATED-BIPHENYLS, Biochemical pharmacology, 46(1), 1993, pp. 186-189
Citations number
19
Categorie Soggetti
Pharmacology & Pharmacy",Biology
Journal title
Biochemical pharmacology → ACNP
ISSN journal
00062952
Volume
46
Issue
1
Year of publication
1993
Pages
186 - 189
Database
ISI
SICI code
0006-2952(1993)46:1<186:AEOMLF>2.0.ZU;2-7
Abstract
Trichlorobiphenyl induced only CYP1A2 mRNA, while pentachlorobiphenyl induced both CYP1A2 and CYP2B1 mRNAs in rat liver. The mRNA levels for these P450s were elevated when ascorbic acid-deficient ODS rats (muta nt rats with a hereditary osteogenic disorder) were fed a diet supplem ented with ascorbic acid. The amount of CYP2B1 mRNA increased rapidly and reached a maximum level of approximately double within 24 hr of in jection of pentachlorobiphenyl. Thereafter, the amount of its mRNA dec reased to a steady level. This pattern was roughly paralleled by chang es in the amount of CYP1A2 mRNA.