THE EFFECT OF 2-SUBSTITUTED THIAZOLIDINE-4(R)-CARBOXYLIC ACIDS ON NONPROTEIN SULFHYDRYL LEVELS AND SULPHURTRANSFERASE ACTIVITIES IN MOUSE-LIVER AND BRAIN

Authors
WLODEK L RADOMSKI J WROBEL M
Citation
L. Wlodek et al., THE EFFECT OF 2-SUBSTITUTED THIAZOLIDINE-4(R)-CARBOXYLIC ACIDS ON NONPROTEIN SULFHYDRYL LEVELS AND SULPHURTRANSFERASE ACTIVITIES IN MOUSE-LIVER AND BRAIN, Biochemical pharmacology, 46(1), 1993, pp. 190-193
Citations number
26
Categorie Soggetti
Pharmacology & Pharmacy",Biology
Journal title
Biochemical pharmacology → ACNP
ISSN journal
00062952
Volume
46
Issue
1
Year of publication
1993
Pages
190 - 193
Database
ISI
SICI code
0006-2952(1993)46:1<190:TEO2TA>2.0.ZU;2-L
Abstract
2-Substituted thiazolidine-4(R)-carboxylic acids (TD) were found to in crease the concentration of non-protein sulphydryls (NPSH) and the act ivity of rhodanese (thiosulphate sulphurtransferase, EC 2.8.1.1) and 3 -mercaptopyruvate sulphurtransferase (EC 2.8.1.2) in mouse liver. Thes e properties suggest TDs are potentially hepatoprotective compounds. H owever TDs also cause depletion of NPSH in the mouse brain and this ma y be the reason for their toxic side effects on the central nervous sy stem.