EFFECT OF PROPRANOLOL HYDROCHLORIDE ON BLOOD-CELL LIPIDS IN RELATION TO PARTITION-COEFFICIENT AND BIOLOGICAL-ACTIVITY

Considering the high lipophilicity of propranolol (log P=3.56), its in teractions with the cell membrane lipids of goat blood have been inves tigated. It is observed that lipid loss after incubation of blood cell s with propranolol hydrochloride in salt glucose medium for varying pe riods of time was accompanied with significant increases in PUFAs. Amo ngst the PUFAs studied the omega3 and omega6 fatty acids, the two impo rtant precursors of eicosenoids, have shown increase in varying amount s. This phenomenon is presumably responsible for the significant cardi ovascular activity of this drug.