Tp. Voloshchuk et al., ALKYLATION OF NUCLEIC-ACID COMPONENTS BY ETHYLENIMINE DERIVATIVES .3.ALKYLATION OF NUCLEOTIDES, Bioorganiceskaa himia, 19(5), 1993, pp. 562-569
Alkylation of mononucleotides by ethylenimine and thioTEPA has been st
udied with the use of ion-exchange chromatography, NMR and UV spectros
copy. Under neutral conditions both phosphate group and heterocyclic b
ase are alkylated, whereas in a slightly acidic medium it is bases tha
t are affected predominantly.