ALKYLATION OF NUCLEIC-ACID COMPONENTS BY ETHYLENIMINE DERIVATIVES .3.ALKYLATION OF NUCLEOTIDES

Authors
VOLOSHCHUK TP PATSKOVSKY YV POTOPALSKY AI
Citation
Tp. Voloshchuk et al., ALKYLATION OF NUCLEIC-ACID COMPONENTS BY ETHYLENIMINE DERIVATIVES .3.ALKYLATION OF NUCLEOTIDES, Bioorganiceskaa himia, 19(5), 1993, pp. 562-569
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Bioorganiceskaa himia → ACNP
ISSN journal
01323423
Volume
19
Issue
5
Year of publication
1993
Pages
562 - 569
Database
ISI
SICI code
0132-3423(1993)19:5<562:AONCBE>2.0.ZU;2-8
Abstract
Alkylation of mononucleotides by ethylenimine and thioTEPA has been st udied with the use of ion-exchange chromatography, NMR and UV spectros copy. Under neutral conditions both phosphate group and heterocyclic b ase are alkylated, whereas in a slightly acidic medium it is bases tha t are affected predominantly.