PRINCIPLES OF DEVELOPMENT OF STANDARD PAN ELS OF SERA WITH LOW CONCENTRATION OF HIV-1 ANTIBODIES FOR ASSESSMENT OF COMMERCIAL ENZYME-IMMUNOASSAY SYSTEMS

The main approaches are defined to the production of sera with the req uired concentration of antibodies to HIV by the dilution method and to formation on their basis of serum panels according to theoretical dis tribution of optic density (OD) values. It was shown to be principally possible to prepare panels of positive sera with low concentration of HIV-specific antibodies in a dry stable form, and their practical imp ortance in the evaluation of the sensitivity of enzyme immunoassays wa s demonstrated. The evaluation of the quality of commercial test syste ms is based on the position and shape of the histogram of OD values di stribution for panel sera for the controlled test systems.