Soft tissue chondroma is a benign cartilaginous tumour most often loca
ted at the extremity of the upper limbs. We report a very unusual case
of soft tissue chondroma due to its location in the sole of the foot
resulting in delayed diagnosis. Diagnosis of soft tissue chondroma was
confirmed by microscopic examination and by immunohistochemistry show
ing S 100 protein in the cells of mature and immature areas. The prese
nce of numerous giant cells is exceptional. Labelling of the giant cel
ls by KP 1 protein in the present case suggest that they are derived f
rom macrophages.