BENZOYLCELLULOSE DERIVATIVES AS CHIRAL STATIONARY PHASES FOR OPEN-TUBULAR COLUMN CHROMATOGRAPHY

The application of cellulose-based stationary phases for chiral separa tions has been extended to open tubular column chromatography. Efficie nt columns were obtained by coating the capillaries with mixtures of c hiral cellulose materials and conventional achiral stationary phases f or gas chromatography. In this study, various siloxane and polyethylen e glycol polymers were used as achiral components and mixed with diffe rent substituted benzoylcellulose derivatives as chiral components. Sy stematic investigations were carried out to determine the optimal rati o for the components of the stationary phase. Depending on the chromat ographic mode-gas chromatography (GC) or supercritical fluid chromatog raphy (SFC)-the stationary phases were found to behave differently. Th e applicability of the technique was demonstrated by the resolution of various racemic compounds. (C) 1993 Wiley-Liss, Inc.