HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY (HPLC) CHIRAL SEPARATIONS OF GUAIFENESIN, METHOCARBAMOL, AND RACEMORPHAN

HPLC chiral separations on silica gel coated with derivatized cellulos e stationary phases are described. Most examples make use of the Chira lcel OD column from Daicel, Inc. With a judiciously chosen mobile phas e, baseline separations of the enantiomers can be achieved. If those s eparations are used as a base for enantiomeric purity determination, d etectable limits of 0.1% of the minor enantiomer are routinely accessi ble. Examples are given concerning separations of guaifenesin, methoca rbamol, and racemorphan. (C) 1993 Wiley-Liss, Inc.