B. Hauser et al., A COMPARATIVE-EVALUATION OF WHEY HYDROLYSATE AND WHEY-PREDOMINANT FORMULAS - HOW WELL DO INFANTS ACCEPT AND TOLERATE THEM, Clinical pediatrics, 32(7), 1993, pp. 433-437
Whey hydrolysate formulas are a recent and important innovation in inf
ant feeding. This study compared clinical tolerance and acceptability
of a whey hydrolysate formula (WH) with those of a whey-predominant fo
rmula (WF) in 45 infants. Four infants (16%) who refused to drink WH f
ormula were eliminated from the study. Mean volume intake was signific
antly lower for WH (120 mL/kg/day) than for WF (147 mL/kg/day; P < .00
1). Consequently, mean caloric intake was also significantly different
: 80 kcal/kg/day (WF) vs 97 kcal/kg/day (WF; P < .001). Nevertheless,
weight gain from birth to 13 weeks of age was nearly identical in both
groups (171% for WH vs 178% for WF). No significant differences were
noted in duration of feeding, number of pauses during feeding, number
of stools per day, or number of regurgitations per day. The lower rate
of caloric intake and the dropout rate of 16% for WH raise questions
about the use of WH formula in normal infants, as has become the case
in some Western European regions.