T. Kitajima et al., ROLE OF ENDOTHELIN AND PLATELET-ACTIVATING-FACTOR IN INDOMETHACIN-INDUCED GASTRIC-MUCOSAL INJURY IN RATS, Digestion, 54(3), 1993, pp. 156-159
The current study was designed to investigate the role of two potent v
asoactive substances, endothelin (ET) and platelet-activating factor (
PAF), in the pathogenesis of indomethacin-induced gastric lesions in r
ats. Treatment with anti-ET antibody before indomethacin administratio
n resulted in a significant decline in the total length of the lesions
as determined by gross evaluation. In contrast, CV-6209, a specific P
AF antagonist, had no effect on the total length of the lesions. The r
esults strongly suggest the incorporation of endogenous ET in the mech
anism of gastric damage after indomethacin administration.