SUBINHIBITORY CONCENTRATIONS OF ANTIBACTERIAL DRUGS AND PSEUDOMONAS-AERUGINOSA VIRULENCE FACTORS

Authors
TRANCASSINI M GIORDANO A MAGNI A CIPRIANI P
Citation
M. Trancassini et al., SUBINHIBITORY CONCENTRATIONS OF ANTIBACTERIAL DRUGS AND PSEUDOMONAS-AERUGINOSA VIRULENCE FACTORS, The New microbiologica, 16(3), 1993, pp. 275-279
Citations number
NO
Categorie Soggetti
Microbiology
Journal title
The New microbiologica
ISSN journal
11217138 → ACNP
Volume
16
Issue
3
Year of publication
1993
Pages
275 - 279
Database
ISI
SICI code
1121-7138(1993)16:3<275:SCOADA>2.0.ZU;2-T
Abstract
Pseudomonas aeruginosa is an important, opportunistic pathogen respons ible for nosocomial infections in the immunocompromised host and resis tant to antibacterial drugs. Its pathogenicity is related to many viru lence factors such as proteases, alginate, exotoxin A and exoenzyme S. Our previous study showed a down-regulation of some P. aeruginosa vir ulence factors by subinhibitory concentrations of antibacterial drugs. This study aimed to compare the effects of subinhibitory concentratio ns of a new difluoroquinolone, PD 131,628, a betalactam, aztreonam and an aminoglycoside, netilmicin.