The incidence of amblyopia was analysed in a group of 20 patients with
early onset esotropia. These patients reached adulthood without any f
orm of previous treatment. The incidence of amblyopia was compared in
a group of 20 patients who received conventional treatment, including
occlusion and early surgical alignment. Only three patients (15%) in t
he untreated group presented with amblyopia, compared with 16 (80%) in
the treated group. After treatment 35% of the control group remained
amblyopic. Spherical anisometropia of more than 2 dioptres was present
in two of the patients with amblyopia in the untreated group, but was
not associated with amblyopia in the control group. Early surgical al
ignment permits the development of peripheral fusion, allowing long te
rm alignment stability, but amblyopia appears to be more common after
surgical alignment.