NEW IMPLICATIONS OF MEMORY MECHANISMS FOR ALZHEIMERS-DISEASE

Authors
ETCHEBERRIGARAY R ITO E OKA K TOFELGREHL B GIBSON GE ALKON DL
Citation
R. Etcheberrigaray et al., NEW IMPLICATIONS OF MEMORY MECHANISMS FOR ALZHEIMERS-DISEASE, Neuroscience research communications, 13, 1993, pp. 190000007-190000010
Citations number
22
Categorie Soggetti
Neurosciences
Journal title
Neuroscience research communications → ACNP
ISSN journal
08936609
Volume
13
Year of publication
1993
Supplement
1
Pages
190000007 - 190000010
Database
ISI
SICI code
0893-6609(1993)13:<190000007:NIOMMF>2.0.ZU;2-P
Abstract
Previous studies of molluscan and mammalian neural networks have impli cated potassium channels, calcium-dependent kinases and a small G-prot ein (Cp20) in associative memory storage. Since Alzheimer's disease is characterized by memory deficits and possible changes in PKC activati on, we studied potassium channel function in AD. Patch-clamp experimen ts revealed the absence of a 113 pS TEA-sensitive K+ channel in fibrob lasts from Alzheimer's but not control patients. These results suggest a role for potassium channel dysfunction in Alzheimer's disease.